In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera)
Identifieur interne : 001270 ( Main/Exploration ); précédent : 001269; suivant : 001271In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera)
Auteurs : Humberto F. Boncristiani [États-Unis] ; Jay D. Evans [États-Unis] ; Yanping Chen [États-Unis] ; Jeff Pettis [États-Unis] ; Charles Murphy [États-Unis] ; Dawn L. Lopez [États-Unis] ; Michael Simone-Finstrom [États-Unis] ; Micheline Strand [États-Unis] ; David R. Tarpy [États-Unis] ; Olav Rueppell [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
The ongoing decline of honey bee health worldwide is a serious economic and ecological concern. One major contributor to the decline are pathogens, including several honey bee viruses. However, information is limited on the biology of bee viruses and molecular interactions with their hosts. An experimental protocol to test these systems was developed, using injections of Israeli Acute Paralysis Virus (IAPV) into honey bee pupae reared ex-situ under laboratory conditions. The infected pupae developed pronounced but variable patterns of disease. Symptoms varied from complete cessation of development with no visual evidence of disease to rapid darkening of a part or the entire body. Considerable differences in IAPV titer dynamics were observed, suggesting significant variation in resistance to IAPV among and possibly within honey bee colonies. Thus, selective breeding for virus resistance should be possible. Gene expression analyses of three separate experiments suggest IAPV disruption of transcriptional homeostasis of several fundamental cellular functions, including an up-regulation of the ribosomal biogenesis pathway. These results provide first insights into the mechanisms of IAPV pathogenicity. They mirror a transcriptional survey of honey bees afflicted with Colony Collapse Disorder and thus support the hypothesis that viruses play a critical role in declining honey bee health.
Url:
DOI: 10.1371/journal.pone.0073429
PubMed: 24039938
PubMed Central: 3764161
Affiliations:
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Boncristiani</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biology, University of North Carolina at Greensboro, Greensboro, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, University of North Carolina at Greensboro, Greensboro, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Evans, Jay D" sort="Evans, Jay D" uniqKey="Evans J" first="Jay D." last="Evans">Jay D. Evans</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chen, Yanping" sort="Chen, Yanping" uniqKey="Chen Y" first="Yanping" last="Chen">Yanping Chen</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pettis, Jeff" sort="Pettis, Jeff" uniqKey="Pettis J" first="Jeff" last="Pettis">Jeff Pettis</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Murphy, Charles" sort="Murphy, Charles" uniqKey="Murphy C" first="Charles" last="Murphy">Charles Murphy</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Soybean Genomics and Improvement, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Soybean Genomics and Improvement, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lopez, Dawn L" sort="Lopez, Dawn L" uniqKey="Lopez D" first="Dawn L." last="Lopez">Dawn L. Lopez</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bee Research Laboratory, Agricultural Research Service of the United States Department of Agriculture, Beltsville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Simone Finstrom, Michael" sort="Simone Finstrom, Michael" uniqKey="Simone Finstrom M" first="Michael" last="Simone-Finstrom">Michael Simone-Finstrom</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Entomology, North Carolina State University, Raleigh, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Entomology, North Carolina State University, Raleigh, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Strand, Micheline" sort="Strand, Micheline" uniqKey="Strand M" first="Micheline" last="Strand">Micheline Strand</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>United States Army Research Office, Division of Life Sciences, Research Triangle Park, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>United States Army Research Office, Division of Life Sciences, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Tarpy, David R" sort="Tarpy, David R" uniqKey="Tarpy D" first="David R." last="Tarpy">David R. Tarpy</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Entomology, North Carolina State University, Raleigh, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Entomology, North Carolina State University, Raleigh, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Rueppell, Olav" sort="Rueppell, Olav" uniqKey="Rueppell O" first="Olav" last="Rueppell">Olav Rueppell</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Biology, University of North Carolina at Greensboro, Greensboro, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, University of North Carolina at Greensboro, Greensboro, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The ongoing decline of honey bee health worldwide is a serious economic and ecological concern. One major contributor to the decline are pathogens, including several honey bee viruses. However, information is limited on the biology of bee viruses and molecular interactions with their hosts. An experimental protocol to test these systems was developed, using injections of Israeli Acute Paralysis Virus (IAPV) into honey bee pupae reared ex-situ under laboratory conditions. The infected pupae developed pronounced but variable patterns of disease. Symptoms varied from complete cessation of development with no visual evidence of disease to rapid darkening of a part or the entire body. Considerable differences in IAPV titer dynamics were observed, suggesting significant variation in resistance to IAPV among and possibly within honey bee colonies. Thus, selective breeding for virus resistance should be possible. Gene expression analyses of three separate experiments suggest IAPV disruption of transcriptional homeostasis of several fundamental cellular functions, including an up-regulation of the ribosomal biogenesis pathway. These results provide first insights into the mechanisms of IAPV pathogenicity. They mirror a transcriptional survey of honey bees afflicted with Colony Collapse Disorder and thus support the hypothesis that viruses play a critical role in declining honey bee health.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vanengelsdorp, D" uniqKey="Vanengelsdorp D">D vanEngelsdorp</name></author><author><name sortKey="Hayes Jr, J" uniqKey="Hayes Jr J">J Hayes Jr</name></author><author><name sortKey="Underwood, Rm" uniqKey="Underwood R">RM Underwood</name></author><author><name sortKey="Pettis, J" uniqKey="Pettis J">J Pettis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellis, Jd" uniqKey="Ellis J">JD Ellis</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author><author><name sortKey="Pettis, Js" uniqKey="Pettis J">JS Pettis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author><author><name sortKey="Schwarz, Rs" uniqKey="Schwarz R">RS Schwarz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cornman, Rs" uniqKey="Cornman R">RS Cornman</name></author><author><name sortKey="Tarpy, Dr" uniqKey="Tarpy D">DR Tarpy</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Jeffreys, L" uniqKey="Jeffreys L">L Jeffreys</name></author><author><name sortKey="Lopez, D" uniqKey="Lopez D">D Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neumann, P" uniqKey="Neumann P">P Neumann</name></author><author><name sortKey="Carreck, Nl" uniqKey="Carreck N">NL Carreck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanengelsdorp, D" uniqKey="Vanengelsdorp D">D vanEngelsdorp</name></author><author><name sortKey="Meixner, Md" uniqKey="Meixner M">MD Meixner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanengelsdorp, D" uniqKey="Vanengelsdorp D">D vanEngelsdorp</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author><author><name sortKey="Saegerman, C" uniqKey="Saegerman C">C Saegerman</name></author><author><name sortKey="Mullin, C" uniqKey="Mullin C">C Mullin</name></author><author><name sortKey="Haubruge, E" uniqKey="Haubruge E">E Haubruge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox Foster, Dl" uniqKey="Cox Foster D">DL Cox-Foster</name></author><author><name sortKey="Conlan, S" uniqKey="Conlan S">S Conlan</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Palacios, G" uniqKey="Palacios G">G Palacios</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Rm" uniqKey="Johnson R">RM Johnson</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author><author><name sortKey="Robinson, Ge" uniqKey="Robinson G">GE Robinson</name></author><author><name sortKey="Berenbaum, Mr" uniqKey="Berenbaum M">MR Berenbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genersch, E" uniqKey="Genersch E">E Genersch</name></author><author><name sortKey="Von Der Ohe, W" uniqKey="Von Der Ohe W">W von der Ohe</name></author><author><name sortKey="Kaatz, H" uniqKey="Kaatz H">H Kaatz</name></author><author><name sortKey="Schroeder, A" uniqKey="Schroeder A">A Schroeder</name></author><author><name sortKey="Otten, C" uniqKey="Otten C">C Otten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nazzi, F" uniqKey="Nazzi F">F Nazzi</name></author><author><name sortKey="Brown, Sp" uniqKey="Brown S">SP Brown</name></author><author><name sortKey="Annoscia, D" uniqKey="Annoscia D">D Annoscia</name></author><author><name sortKey="Del Piccolo, F" uniqKey="Del Piccolo F">F Del Piccolo</name></author><author><name sortKey="Di Prisco, G" uniqKey="Di Prisco G">G Di Prisco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Sj" uniqKey="Martin S">SJ Martin</name></author><author><name sortKey="Highfield, Ac" uniqKey="Highfield A">AC Highfield</name></author><author><name sortKey="Brettell, L" uniqKey="Brettell L">L Brettell</name></author><author><name sortKey="Villalobos, Em" uniqKey="Villalobos E">EM Villalobos</name></author><author><name sortKey="Budge, Ge" uniqKey="Budge G">GE Budge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Dl" uniqKey="Anderson D">DL Anderson</name></author><author><name sortKey="Trueman, Jwh" uniqKey="Trueman J">JWH Trueman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenkranz, P" uniqKey="Rosenkranz P">P Rosenkranz</name></author><author><name sortKey="Aumeier, P" uniqKey="Aumeier P">P Aumeier</name></author><author><name sortKey="Ziegelmann, B" uniqKey="Ziegelmann B">B Ziegelmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boecking, O" uniqKey="Boecking O">O Boecking</name></author><author><name sortKey="Genersch, E" uniqKey="Genersch E">E Genersch</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De, Mirandajr" uniqKey="De M">MirandaJR de</name></author><author><name sortKey="Genersch, E" uniqKey="Genersch E">E Genersch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genersch, E" uniqKey="Genersch E">E Genersch</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Allen, Mf" uniqKey="Allen M">MF Allen</name></author><author><name sortKey="Ball, Bv" uniqKey="Ball B">BV Ball</name></author><author><name sortKey="White, Rf" uniqKey="White R">RF White</name></author><author><name sortKey="Antoniw, Jf" uniqKey="Antoniw J">JF Antoniw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey, L" uniqKey="Bailey L">L Bailey</name></author><author><name sortKey="Ball, Bv" uniqKey="Ball B">BV Ball</name></author><author><name sortKey="Perry, Jn" uniqKey="Perry J">JN Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ball, B" uniqKey="Ball B">B Ball</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Maori, E" uniqKey="Maori E">E Maori</name></author><author><name sortKey="Lavi, S" uniqKey="Lavi S">S Lavi</name></author><author><name sortKey="Mozes Koch, R" uniqKey="Mozes Koch R">R Mozes-Koch</name></author><author><name sortKey="Gantman, Y" uniqKey="Gantman Y">Y Gantman</name></author><author><name sortKey="Peretz, Y" uniqKey="Peretz Y">Y Peretz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Azzami, K" uniqKey="Azzami K">K Azzami</name></author><author><name sortKey="Ritter, W" uniqKey="Ritter W">W Ritter</name></author><author><name sortKey="Tautz, J" uniqKey="Tautz J">J Tautz</name></author><author><name sortKey="Beier, H" uniqKey="Beier H">H Beier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Yp" uniqKey="Chen Y">YP Chen</name></author><author><name sortKey="Siede, R" uniqKey="Siede R">R Siede</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bonning, Bc" uniqKey="Bonning B">BC Bonning</name></author><author><name sortKey="Miller, Wa" uniqKey="Miller W">WA Miller</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Maori, E" uniqKey="Maori E">E Maori</name></author><author><name sortKey="Paldi, N" uniqKey="Paldi N">N Paldi</name></author><author><name sortKey="Shafir, S" uniqKey="Shafir S">S Shafir</name></author><author><name sortKey="Kalev, H" uniqKey="Kalev H">H Kalev</name></author><author><name sortKey="Tsur, E" uniqKey="Tsur E">E Tsur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scotti, Pd" uniqKey="Scotti P">PD Scotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Nf" uniqKey="Moore N">NF Moore</name></author><author><name sortKey="Kearns, A" uniqKey="Kearns A">A Kearns</name></author><author><name sortKey="Pullin, Jsk" uniqKey="Pullin J">JSK Pullin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chevin, A" uniqKey="Chevin A">A Chevin</name></author><author><name sortKey="Schurr, F" uniqKey="Schurr F">F Schurr</name></author><author><name sortKey="Blanchard, P" uniqKey="Blanchard P">P Blanchard</name></author><author><name sortKey="Thiery, R" uniqKey="Thiery R">R Thiery</name></author><author><name sortKey="Ribiere, M" uniqKey="Ribiere M">M Ribiere</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Di Prisco, G" uniqKey="Di Prisco G">G Di Prisco</name></author><author><name sortKey="Pennacchio, F" uniqKey="Pennacchio F">F Pennacchio</name></author><author><name sortKey="Caprio, E" uniqKey="Caprio E">E Caprio</name></author><author><name sortKey="Boncristiani, Hf" uniqKey="Boncristiani H">HF Boncristiani</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author><author><name sortKey="Aronstein, K" uniqKey="Aronstein K">K Aronstein</name></author><author><name sortKey="Chen, Yp" uniqKey="Chen Y">YP Chen</name></author><author><name sortKey="Hetru, C" uniqKey="Hetru C">C Hetru</name></author><author><name sortKey="Imler, Jl" uniqKey="Imler J">JL Imler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boncristiani, H" uniqKey="Boncristiani H">H Boncristiani</name></author><author><name sortKey="Underwood, R" uniqKey="Underwood R">R Underwood</name></author><author><name sortKey="Schwarz, R" uniqKey="Schwarz R">R Schwarz</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author><author><name sortKey="Pettis, J" uniqKey="Pettis J">J Pettis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, Yj" uniqKey="Jeong Y">YJ Jeong</name></author><author><name sortKey="Choi, Hw" uniqKey="Choi H">HW Choi</name></author><author><name sortKey="Shin, Hs" uniqKey="Shin H">HS Shin</name></author><author><name sortKey="Cui, Xs" uniqKey="Cui X">XS Cui</name></author><author><name sortKey="Kim, Nh" uniqKey="Kim N">NH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walsh, Ps" uniqKey="Walsh P">PS Walsh</name></author><author><name sortKey="Metzger, Da" uniqKey="Metzger D">DA Metzger</name></author><author><name sortKey="Higuchi, R" uniqKey="Higuchi R">R Higuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tarpy, Dr" uniqKey="Tarpy D">DR Tarpy</name></author><author><name sortKey="Caren, Jr" uniqKey="Caren J">JR Caren</name></author><author><name sortKey="Delaney, Da" uniqKey="Delaney D">DA Delaney</name></author><author><name sortKey="Sammataro, D" uniqKey="Sammataro D">D Sammataro</name></author><author><name sortKey="Finley, J" uniqKey="Finley J">J Finley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delaney, Da" uniqKey="Delaney D">DA Delaney</name></author><author><name sortKey="Keller, Jj" uniqKey="Keller J">JJ Keller</name></author><author><name sortKey="Caren, Jr" uniqKey="Caren J">JR Caren</name></author><author><name sortKey="Tarpy, Dr" uniqKey="Tarpy D">DR Tarpy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Yp" uniqKey="Chen Y">YP Chen</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Hammond, J" uniqKey="Hammond J">J Hammond</name></author><author><name sortKey="Hsu, Ht" uniqKey="Hsu H">HT Hsu</name></author><author><name sortKey="Evans, J" uniqKey="Evans J">J Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iqbal, J" uniqKey="Iqbal J">J Iqbal</name></author><author><name sortKey="Mueller, U" uniqKey="Mueller U">U Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grabensteiner, E" uniqKey="Grabensteiner E">E Grabensteiner</name></author><author><name sortKey="Nowotny, N" uniqKey="Nowotny N">N Nowotny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simone, M" uniqKey="Simone M">M Simone</name></author><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author><author><name sortKey="Spivak, M" uniqKey="Spivak M">M Spivak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pettis, Js" uniqKey="Pettis J">JS Pettis</name></author><author><name sortKey="Vanengelsdorp, D" uniqKey="Vanengelsdorp D">D vanEngelsdorp</name></author><author><name sortKey="Johnson, J" uniqKey="Johnson J">J Johnson</name></author><author><name sortKey="Dively, G" uniqKey="Dively G">G Dively</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lemaitre, B" uniqKey="Lemaitre B">B Lemaitre</name></author><author><name sortKey="Hoffmann, J" uniqKey="Hoffmann J">J Hoffmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ourth, Dd" uniqKey="Ourth D">DD Ourth</name></author><author><name sortKey="Renis, He" uniqKey="Renis H">HE Renis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shelby, Ks" uniqKey="Shelby K">KS Shelby</name></author><author><name sortKey="Popham, Hj" uniqKey="Popham H">HJ Popham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clem, Rj" uniqKey="Clem R">RJ Clem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bustin, Sa" uniqKey="Bustin S">SA Bustin</name></author><author><name sortKey="Benes, V" uniqKey="Benes V">V Benes</name></author><author><name sortKey="Garson, Ja" uniqKey="Garson J">JA Garson</name></author><author><name sortKey="Hellemans, J" uniqKey="Hellemans J">J Hellemans</name></author><author><name sortKey="Huggett, J" uniqKey="Huggett J">J Huggett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radonic, A" uniqKey="Radonic A">A Radonic</name></author><author><name sortKey="Thulke, S" uniqKey="Thulke S">S Thulke</name></author><author><name sortKey="Bae, Hg" uniqKey="Bae H">HG Bae</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Siegert, W" uniqKey="Siegert W">W Siegert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lilly, St" uniqKey="Lilly S">ST Lilly</name></author><author><name sortKey="Drummond, Rsm" uniqKey="Drummond R">RSM Drummond</name></author><author><name sortKey="Pearson, Mn" uniqKey="Pearson M">MN Pearson</name></author><author><name sortKey="Macdiarmid, Rm" uniqKey="Macdiarmid R">RM MacDiarmid</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Das, S" uniqKey="Das S">S Das</name></author><author><name sortKey="Dasgupta, A" uniqKey="Dasgupta A">A Dasgupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, Me" uniqKey="Clark M">ME Clark</name></author><author><name sortKey="Hammerle, T" uniqKey="Hammerle T">T Hammerle</name></author><author><name sortKey="Wimmer, E" uniqKey="Wimmer E">E Wimmer</name></author><author><name sortKey="Dasgupta, A" uniqKey="Dasgupta A">A Dasgupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfingsten, Js" uniqKey="Pfingsten J">JS Pfingsten</name></author><author><name sortKey="Costantino, Da" uniqKey="Costantino D">DA Costantino</name></author><author><name sortKey="Kieft, Js" uniqKey="Kieft J">JS Kieft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishiyama, T" uniqKey="Nishiyama T">T Nishiyama</name></author><author><name sortKey="Yamamoto, H" uniqKey="Yamamoto H">H Yamamoto</name></author><author><name sortKey="Uchiumi, T" uniqKey="Uchiumi T">T Uchiumi</name></author><author><name sortKey="Nakashima, N" uniqKey="Nakashima N">N Nakashima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spahn, Cmt" uniqKey="Spahn C">CMT Spahn</name></author><author><name sortKey="Jan, E" uniqKey="Jan E">E Jan</name></author><author><name sortKey="Mulder, A" uniqKey="Mulder A">A Mulder</name></author><author><name sortKey="Grassucci, Ra" uniqKey="Grassucci R">RA Grassucci</name></author><author><name sortKey="Sarnow, P" uniqKey="Sarnow P">P Sarnow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillespie, Jj" uniqKey="Gillespie J">JJ Gillespie</name></author><author><name sortKey="Johnston, Js" uniqKey="Johnston J">JS Johnston</name></author><author><name sortKey="Cannone, Jj" uniqKey="Cannone J">JJ Cannone</name></author><author><name sortKey="Gutell, Rr" uniqKey="Gutell R">RR Gutell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bachand, F" uniqKey="Bachand F">F Bachand</name></author><author><name sortKey="Lackner, Dh" uniqKey="Lackner D">DH Lackner</name></author><author><name sortKey="Bahler, J" uniqKey="Bahler J">J Bahler</name></author><author><name sortKey="Silver, Pa" uniqKey="Silver P">PA Silver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Granneman, S" uniqKey="Granneman S">S Granneman</name></author><author><name sortKey="Baserga, Sj" uniqKey="Baserga S">SJ Baserga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montanaro, L" uniqKey="Montanaro L">L Montanaro</name></author><author><name sortKey="Trere, D" uniqKey="Trere D">D Trere</name></author><author><name sortKey="Derenzini, M" uniqKey="Derenzini M">M Derenzini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgado Palacin, L" uniqKey="Morgado Palacin L">L Morgado-Palacin</name></author><author><name sortKey="Llanos, S" uniqKey="Llanos S">S Llanos</name></author><author><name sortKey="Serrano, M" uniqKey="Serrano M">M Serrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hardwick, Jm" uniqKey="Hardwick J">JM Hardwick</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Groppo, R" uniqKey="Groppo R">R Groppo</name></author><author><name sortKey="Palmenberg, Ac" uniqKey="Palmenberg A">AC Palmenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaw, T" uniqKey="Shaw T">T Shaw</name></author><author><name sortKey="Martin, P" uniqKey="Martin P">P Martin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ojosnegros, S" uniqKey="Ojosnegros S">S Ojosnegros</name></author><author><name sortKey="Beerenwinkel, N" uniqKey="Beerenwinkel N">N Beerenwinkel</name></author><author><name sortKey="Antal, T" uniqKey="Antal T">T Antal</name></author><author><name sortKey="Nowak, Ma" uniqKey="Nowak M">MA Nowak</name></author><author><name sortKey="Escarmis, C" uniqKey="Escarmis C">C Escarmis</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Boncristiani, Humberto F" sort="Boncristiani, Humberto F" uniqKey="Boncristiani H" first="Humberto F." last="Boncristiani">Humberto F. Boncristiani</name></region><name sortKey="Chen, Yanping" sort="Chen, Yanping" uniqKey="Chen Y" first="Yanping" last="Chen">Yanping Chen</name><name sortKey="Evans, Jay D" sort="Evans, Jay D" uniqKey="Evans J" first="Jay D." last="Evans">Jay D. Evans</name><name sortKey="Lopez, Dawn L" sort="Lopez, Dawn L" uniqKey="Lopez D" first="Dawn L." last="Lopez">Dawn L. Lopez</name><name sortKey="Murphy, Charles" sort="Murphy, Charles" uniqKey="Murphy C" first="Charles" last="Murphy">Charles Murphy</name><name sortKey="Pettis, Jeff" sort="Pettis, Jeff" uniqKey="Pettis J" first="Jeff" last="Pettis">Jeff Pettis</name><name sortKey="Rueppell, Olav" sort="Rueppell, Olav" uniqKey="Rueppell O" first="Olav" last="Rueppell">Olav Rueppell</name><name sortKey="Simone Finstrom, Michael" sort="Simone Finstrom, Michael" uniqKey="Simone Finstrom M" first="Michael" last="Simone-Finstrom">Michael Simone-Finstrom</name><name sortKey="Strand, Micheline" sort="Strand, Micheline" uniqKey="Strand M" first="Micheline" last="Strand">Micheline Strand</name><name sortKey="Tarpy, David R" sort="Tarpy, David R" uniqKey="Tarpy D" first="David R." last="Tarpy">David R. Tarpy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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